Liver Pathology After Hematopoietic Stem Cell Transplantation.

Ragini Phansalkar, Neeraja Kambham, Vivek Charu

Journal: Surgical pathology clinics 2023;16(3):519-532

PMID: 37536886

Full Text on Elsevier Science View on PubMed

Abstract

Hematopoietic stem cell transplantation is used to treat a variety of hematologic malignancies and autoimmune conditions. The immunosuppressive medications as well as other therapies used both before and after transplantation leave patients susceptible to a wide spectrum of complications, including liver injury. Causes for liver damage associated with stem cell transplantation include sinusoidal obstruction syndrome, graft-versus-host disease, iron overload, and opportunistic infection. Here, the authors review the clinical and pathological findings of these etiologies of liver injury and provide a framework for diagnosis.

Address: Department of Pathology, Lane Building, L235, 300 Pasteur Drive, Stanford, CA 94305, USA.; Department of Pathology, Lane Building, L235, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Medicine, Quantitative Sciences Unit, Stanford, CA, USA. Electronic address: [email protected].

DOI: 10.1016/j.path.2023.04.007

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MeSH Terms: Humans, Hematopoietic Stem Cell Transplantation, Liver Diseases, Hepatic Veno-Occlusive Disease, Iron Overload