Circular RNAs-mediated angiogenesis in human cancers.

Sajad Najafi, Habib Haybar, Ava Nasrolahi, Shirin Azizidoost, Maryam Farzaneh, Mohammad Mighani, Piotr Dzięgiel, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Ahmad Reza Assareh, Bartosz Kempisty

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023;25(11):3101-3121

PMID: 37039938

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Abstract

Circular RNAs (circRNAs) as small non-coding RNAs with cell, tissue, or organ-specific expression accomplish a broad array of functions in physiological and pathological processes such as cancer development. Angiogenesis, a complicated multistep process driving a formation of new blood vessels, speeds up tumor progression by supplying nutrients as well as energy. Abnormal expression of circRNAs reported to affect tumor development through impressing angiogenesis. Such impacts are introduced as constant with different tumorigenic features known as "hallmarks of cancer". In addition, deregulated circRNAs show possibilities to prognosis and diagnosis both in the prophecy of prognosis in malignancies and also their prejudice from healthy individuals. In the present review article, we have evaluated the angiogenic impacts and anti-angiogenic managements of circRNAs in human cancers.

Address: Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; School of Medicine, Golestan University of Medical Sciences, Golestan, Iran.; Cardiovascular Research Center, Nemazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Institute of Veterinary Medicine, Department of Veterinary Surgery, Nicolaus Copernicus University, Torun, Poland.; Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical University, Wrocław, Poland.; North Carolina State University College of Agriculture and Life Sciences, Raleigh, NC, 27695, US.; Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368, Wroclaw, Poland.; Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [email protected].; Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [email protected].

DOI: 10.1007/s12094-023-03178-6

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https://dx.doi.org/10.1007/s12094-023-03178-6

MeSH Terms: Humans, RNA, Circular, Neoplasms, Prognosis, Carcinogenesis, Immunotherapy