Non-histone binding functions of PHD fingers.

Nitika Gaurav, Tatiana G Kutateladze

Journal: Trends in biochemical sciences 2023;48(7):610-617

PMID: 37061424

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Abstract

Plant homeodomain (PHD) fingers comprise a large and well-established family of epigenetic readers that recognize histone H3. A typical PHD finger binds to the unmodified or methylated amino-terminal tail of H3. This interaction is highly specific and can be regulated by post-translational modifications (PTMs) in H3 and other domains present in the protein. However, a set of PHD fingers has recently been shown to bind non-histone proteins, H3 mimetics, and DNA. In this review, we highlight the molecular mechanisms by which PHD fingers interact with ligands other than the amino terminus of H3 and discuss similarities and differences in engagement with histone and non-histone binding partners.

Address: Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2023.03.005

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MeSH Terms: PHD Zinc Fingers, DNA-Binding Proteins, Histones, Plants, Protein Binding