Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer.

Ellen K Janke, Silke B Chalmers, Sarah J Roberts-Thomson, Gregory R Monteith

Journal: Cell calcium 2023;112():102741

PMID: 37060674

Full Text on Elsevier Science View on PubMed

Abstract

Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca signalling and EMT will be explored. An overview of the Ca pathways that are remodelled as a consequence of EMT is provided and the role of Ca signalling in regulating EMT and its significance is considered. Ca signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca signalling is to be manipulated with the aim of therapeutic intervention in cancer.

Address: School of Pharmacy, The University of Queensland, 20 Cornwall Street, Woolloongabba, Brisbane, Queensland, 4102, Australia.; Department of Biomedicine, Aarhus University, Nordre Ringgade 1, Aarhus C, 8000, Denmark.; School of Pharmacy, The University of Queensland, 20 Cornwall Street, Woolloongabba, Brisbane, Queensland, 4102, Australia. Electronic address: [email protected].

DOI: 10.1016/j.ceca.2023.102741

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MeSH Terms: Humans, Calcium, Neoplasms, Signal Transduction, Epithelial-Mesenchymal Transition