Immunity to pathogenic fungi in the eye.

Serena Abbondante, Sixto M Leal, Heather L Clark, Bridget Ratitong, Yan Sun, Li-Jun Ma, Eric Pearlman

Journal: Seminars in immunology 2023;67():101753

PMID: 37060806

Abstract

Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.

Copyright © 2023. Published by Elsevier Ltd.

Address: Department of Ophthalmology, and Department of Physiology and Biophysics, University of California, Irvine, CA, USA.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.; University of Rochester Medical Center, Rochester NY, USA.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Ophthalmic Research, Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.; Department of Ophthalmology, and Department of Physiology and Biophysics, University of California, Irvine, CA, USA. Electronic address: [email protected].
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