The metabolic cross-talk between cancer and T cells.

Silvia Cadenas-De Miguel, Giulia Lucianer, Ilaria Elia

Journal: Trends in biochemical sciences 2023;48(7):597-609

PMID: 37080875

Full Text on Elsevier Science View on PubMed

Abstract

The metabolic cross-talk between cancer cells and T cells dictates cancer formation and progression. These cells possess metabolic plasticity. Thus, they adapt their metabolic profile to meet their phenotypic requirements. However, the nutrient microenvironment of a tumor is a very hostile niche in which these cells are forced to compete for the available nutrients. The hyperactive metabolism of tumor cells often outcompetes the antitumorigenic CD8 T cells while promoting the protumorigenic exhausted CD8 T cells and T regulatory (T) cells. Thus, cancer cells elude the immune response and spread in an uncontrolled manner. Identifying the metabolic pathways necessary to shift the balance from a protumorigenic to an antitumorigenic immune phenotype is essential to potentiate antitumor immunity.

Address: Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2023.03.004

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https://medlineplus.gov/cancer.html

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https://antibodies.cancer.gov/detail/CPTC-CD8A-1

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0968...

MeSH Terms: Humans, CD8-Positive T-Lymphocytes, Tumor Microenvironment, Neoplasms