Emerging roles of long non-coding RNA FTX in human disorders.

Fatemeh Khojasteh Pour, Mohadeseh Sheykhi-Sabzehpoush, Majid Ghasemian, Mohammad Mighani, Mehdi Moghanibashi, Razieh Mohammad Jafari, Maciej Zabel, Piotr Dzięgiel, Maryam Farzaneh, Bartosz Kempisty

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023;25(10):2812-2831

PMID: 37095425

Full Text on Springer View on PubMed

Abstract

Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to xist) is an evolutionarily conserved lncRNA that is located upstream of XIST and regulates its expression. FTX participates in progression of various malignancy including gastric cancer, glioma, ovarian cancer, pancreatic cancer, and retinoblastoma. Also, FTX can be involved in the pathogenesis of non-cancerous disorders such as endometriosis and stroke. FTX acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-186, miR-200a-3p, miR-215-3p, and miR-153-3p to regulate the expression of their downstream target. FTX by targeting various signaling pathways including Wnt/β-catenin, PI3K/Akt, SOX4, PDK1/PKB/GSK-3β, TGF-β1, FOXA2, and PPARγ regulate molecular mechanism involved in various disorders. Dysregulation of FTX is associated with an increased risk of various disorders. Therefore, FTX and its downstream targets may be suitable biomarkers for the diagnosis and treatment of human malignancies. In this review, we summarized the emerging roles of FTX in human cancerous and non-cancerous cells.

Address: Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.; Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; School of Medicine, Golestan University of Medical Sciences, Golestan, Iran.; Department of Genetics, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.; Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Division of Anatomy and Histology, University of Zielona Góra, 65-046, Zielona Góra, Poland.; Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368, Wroclaw, Poland.; Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [email protected].; Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical, University, Wrocław, Poland. [email protected].; Institute of Veterinary Medicine, Department of Veterinary Surgery, Nicolaus Copernicus University, Torun, Poland. [email protected].; North Carolina State University College of Agriculture and Life Sciences, Raleigh, NC, 27695, USA. [email protected].

DOI: 10.1007/s12094-023-03163-z

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https://dx.doi.org/10.1007/s12094-023-03163-z

MeSH Terms: Female, Humans, RNA, Long Noncoding, Glycogen Synthase Kinase 3 beta, Phosphatidylinositol 3-Kinases, MicroRNAs, Signal Transduction, SOXC Transcription Factors