Physical biomarkers for human hematopoietic stem and progenitor cells.

Motomu Tanaka, Judith Thoma, Laura Poisa-Beiro, Patrick Wuchter, Volker Eckstein, Sascha Dietrich, Caroline Pabst, Carsten Müller-Tidow, Takao Ohta, Anthony D Ho

Journal: Cells & development 2023;174():203845

PMID: 37116713

Free Full Text on Elsevier Science View on PubMed

Abstract

Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC-niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined in vitro niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs.

Address: Physical Chemistry of Biosystems, Institute of Physical Chemistry, INF253, Heidelberg University, 69120 Heidelberg, Germany; Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University, 606-8501 Kyoto, Japan. Electronic address: [email protected].; Physical Chemistry of Biosystems, Institute of Physical Chemistry, INF253, Heidelberg University, 69120 Heidelberg, Germany.; Department of Medicine V, Heidelberg University, INF410, 69120 Heidelberg, Germany.; Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University, 606-8501 Kyoto, Japan.; Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University, 606-8501 Kyoto, Japan; Department of Medicine V, Heidelberg University, INF410, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit Heidelberg, European Molecular Biology Laboratory (EMBL), Heidelberg University, 69120 Heidelberg, Germany. Electronic address: [email protected].

DOI: 10.1016/j.cdev.2023.203845

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/acutemyeloidleukemia.html

MeSH Terms: Humans, Hematopoietic Stem Cells, Bone Marrow, Hematopoietic Stem Cell Transplantation, Bone Marrow Cells, Leukemia, Myeloid, Acute