Updates in Cardiorenal Syndrome.

Wendy McCallum, Jeffrey M Testani

Journal: The Medical clinics of North America 2023;107(4):763-780

PMID: 37258013

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Abstract

Cardiorenal syndrome is a term that refers to a collection of disorders involving both the heart and kidneys, encompassing multi-directional pathways between the 2 organs mediated through low arterial perfusion, venous congestion, and neurohormonal activation. The pathophysiology is complex and includes hemodynamic and neurohormonal changes, but inconsistent findings from recent studies suggest this is very heterogenous disorder. Management for ADHF remains focused on decongestion and neurohormonal blockade to overcome the intense sodium and fluid avidity of the CRS.

Address: Division of Nephrology, Tufts Medical Center, 800 Washington Street, Box 391, Boston, MA 02111, USA. Electronic address: [email protected].; Division of Cardiovascular Medicine, Yale School of Medicine, PO Box 208017, New Haven, CT 06520, USA.

DOI: 10.1016/j.mcna.2023.03.011

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MeSH Terms: Humans, Cardio-Renal Syndrome, Heart Failure