Targeting DNA methyltransferases in non-small-cell lung cancer.

Minnatallah Al-Yozbaki, Ibtissam Jabre, Naeem H Syed, Cornelia M Wilson

Journal: Seminars in cancer biology 2022;83():77-87

PMID: 33486076

Full Text on Elsevier Science View on PubMed

Abstract

Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.

Address: Canterbury Christ Church University, School of Human and Life Sciences, Life Sciences Industry Liaison Lab, Sandwich, UK.; Dept. of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.; Canterbury Christ Church University, School of Human and Life Sciences, Life Sciences Industry Liaison Lab, Sandwich, UK; University of Liverpool, Institute of Translation Medicine, Dept of Molecular & Clinical Cancer Medicine, UK. Electronic address: [email protected].

DOI: 10.1016/j.semcancer.2021.01.005

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MeSH Terms: Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, DNA, DNA Methylation, DNA Modification Methylases, Epigenesis, Genetic, Humans, Lung Neoplasms