Radix Ranunculi ternati: review of its chemical constituents, pharmacology, quality control and clinical applications.

Changlin Wang, Jieqiong Wang, Mingzhou Gao, Peng Gao, Dongmei Gao, Hao Zhang, Xiangyu Mu, Mingqi Qiao

Journal: The Journal of pharmacy and pharmacology 2022;74(7):930-952

PMID: 35596792

Abstract

OBJECTIVES

Radix ranunculi ternati (RRT) is widely used as traditional and folk medicine distributed in China, as well as in Kyushu and Shikoku in Japan. Although RRT has a short history of use as medicine, it has a high medicinal value. This study summarizes the research progress on the chemical constituents, pharmacological activity, quality control measures and clinical applications to provide a valuable and exhaustive reference for the development and application of RRT.

KEY FINDINGS

Phytochemical studies showed that this plant mainly contains glycosides, organic acids, esters, sterols, flavonoids, alkaloids and volatile oils. The pharmacological activity of RRT includes immune regulation, anti-tumour, anti-tuberculosis, antioxidant, antibacterial, hepatoprotective and anti-inflammatory effects. This plant is especially effective in the treatment of cancer, tuberculosis, thyroid and nasopharynges disorders.

© The Author(s) 2022. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: [email protected].

Address: School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.; Research and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan 250355, China.; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
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