Flavonoids exert potential in the management of hypertensive disorders in pregnancy.

Olga Golubnitschaja, Kamil Biringer, Peter Kubatka, Peter Kruzliak, Denis Baranenko, Elmira Eminova, Robert Prosecky, Mariusz Adamek, Martin Caprnda, Ludovit Gaspar, Alena Mazurakova, Dietrich Büsselberg, Martin Kello, Martin Pec, Martin Jozef Pec, Terezia Pribulova, Jana Sivakova, Erik Kudela, Marek Samec, Lenka Koklesova

Journal: Pregnancy hypertension 2022;29():72-85

PMID: 35803199

Full Text on Elsevier Science View on PubMed

Abstract

Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if not treated, can result in serious health consequences for the mother and the child. Flavonoids are bioactive secondary metabolites commonly found in fruits, vegetables, green tea, whole grains, and medicinal plants. Flavonoids exert potent protective efficacy in experimental models of hypertensive disorders in pregnancy, especially preeclampsia, demonstrated through their capacity to modulate inflammatory responses, oxidative stress, and vascular dysfunction. In addition to their potential as therapeutics, flavonoids or flavonoid-rich food could be helpful to decrease the risk of hypertensive disorders in pregnancy when included in the diet pattern before and during pregnancy. However, the clinical evaluation of the potential capacity of flavonoids in hypertensive disorders in pregnancy is insufficient. Due to promising results from experimental studies, we highlight the need for the evaluation of flavonoids also in an appropriate clinical setting, which can be, together with proper preventive strategies, helpful in the overall management of hypertensive disorders in pregnancy.

Address: Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.; Department of Pathological Physiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.; 1st Department of Internal Diseases, University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.; Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.; Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar.; European Association for Predictive, Preventive and Personalised Medicine, EPMA, Brussels, Belgium; Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.; Faculty of Health Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia.; 1(st) Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.; Department of Thoracic Surgery, Medical University of Silesia, Katowice, Poland.; International Clinical Research Centre, Masaryk University and St. Annés University Hospital, Brno, Czech Republic; 2(nd) Department of Internal Medicine, Faculty of Medicine, Masaryk University and St. Annés University Hospital, Brno, Czech Republic.; International Research Centre "Biotechnologies of the Third Millennium", Faculty of Biotechnologies (BioTech), ITMO University, Saint-Petersburg, Russian Federation.; 2(nd) Department of Surgery, Faculty of Medicine, Masaryk University and St. Annés University Hospital, Brno, Czech Republic. Electronic address: [email protected].; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Electronic address: [email protected].; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Electronic address: [email protected].

DOI: 10.1016/j.preghy.2022.06.007

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MeSH Terms: Child, Female, Flavonoids, Humans, Hypertension, Pregnancy-Induced, Pre-Eclampsia, Pregnancy, Tea, Vegetables