Molecular links between allergy and cancer.

Axel Lorentz, Sabrina Bilotta, Mehtap Civelek

Journal: Trends in molecular medicine 2022;28(12):1070-1081

PMID: 35794030

Full Text on Elsevier Science View on PubMed

Abstract

Epidemiologic studies show both positive and negative associations between allergies and cancer. Allergic diseases may protect against tumorigenesis by promoting the immune surveillance, while carcinogenesis may be promoted through inflammatory responses from allergies. Histamine receptor antagonists are the focus of recent cancer studies because of their promising beneficial effect on tumor development. Also, cytokines, particularly IL-4 or IL-33, IgE as well as allergy-related immune cells such as eosinophils can contribute to tumor growth suppression. Depending on cancer types, cancer therapy may be more beneficial when considering combinatorial immunotherapy. In this review, we give an overview on molecular links between allergies and cancer.

Address: Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany. Electronic address: [email protected].; Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany.

DOI: 10.1016/j.molmed.2022.06.003

Link outs

Free resources

Medical:

https://medlineplus.gov/allergy.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Immunoglobulin E, Hypersensitivity, Immunotherapy, Cytokines, Neoplasms