Repurposing biomedical muscle tissue engineering for cellular agriculture: challenges and opportunities.

Mohamadmahdi Samandari, Farnoosh Saeedinejad, Jacob Quint, Sharon Xin Ying Chuah, Razieh Farzad, Ali Tamayol

Journal: Trends in biotechnology 2023;41(7):887-906

PMID: 36914431

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Abstract

Cellular agriculture is an emerging field rooted in engineering meat-mimicking cell-laden structures using tissue engineering practices that have been developed for biomedical applications, including regenerative medicine. Research and industrial efforts are focused on reducing the cost and improving the throughput of cultivated meat (CM) production using these conventional practices. Due to key differences in the goals of muscle tissue engineering for biomedical versus food applications, conventional strategies may not be economically and technologically viable or socially acceptable. In this review, these two fields are critically compared, and the limitations of biomedical tissue engineering practices in achieving the important requirements of food production are discussed. Additionally, the possible solutions and the most promising biomanufacturing strategies for cellular agriculture are highlighted.

Address: Department of Biomedical Engineering, University of Connecticut, Farmington, CT, USA. Electronic address: [email protected].; Department of Biomedical Engineering, University of Connecticut, Farmington, CT, USA.; Food Science and Human Nutrition Department, Florida Sea Grant and Global Food Systems Institute, University of Florida, Gainesville, FL, USA.; Food Science and Human Nutrition Department, Florida Sea Grant and Global Food Systems Institute, University of Florida, Gainesville, FL, USA. Electronic address: [email protected].; Department of Biomedical Engineering, University of Connecticut, Farmington, CT, USA. Electronic address: [email protected].

DOI: 10.1016/j.tibtech.2023.02.002

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MeSH Terms: Tissue Engineering, Biomedical Engineering, Regenerative Medicine, Muscles