Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems.

Yaochong Tan, Xueting Dong, Donglin Zhuang, Buzi Cao, Hua Jiang, Qingnan He, Mingyi Zhao

Journal: Molecular and cellular biochemistry 2023;478(12):2695-2719

PMID: 36913150

Abstract

Since ferroptosis was first described as an iron-dependent cell death pattern in 2012, there has been increasing interest in ferroptosis research. In view of the immense potential of ferroptosis in treatment efficacy and its rapid development in recent years, it is essential to track and summarize the latest research in this field. However, few writers have been able to draw on any systematic investigation into this field based on human body organ systems. Hence, in this review, we provide a comprehensive description of the latest progress in unveiling the roles and functions, as well as the therapeutic potential of ferroptosis, in treating diseases from the aspects of 11 human body organ systems (including the nervous system, respiratory system, digestive system, urinary system, reproductive system, integumentary system, skeletal system, immune system, cardiovascular system, muscular system, and endocrine system) in the hope of providing references for further understanding the pathogenesis of related diseases and bringing an innovative train of thought for reformative clinical treatment.

Address: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.; Medical School of Xiangya, Central South University, Changsha, 410013, Hunan, China.; Department of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100037, China.; Hunan Normal University School of Medicine, Changsha, 410081, Hunan, China.; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China. [email protected].; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. [email protected].; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. [email protected].

DOI: 10.1007/s11010-023-04694-3

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https://doi.org/10.1007/s11010-023-04694-3

MeSH Terms: Humans, Ferroptosis, Human Body, Cell Death, Iron