Proton Radiotherapy for Skull-Base Malignancies: Imaging Considerations of Radiotherapy and Complications.

Adam L Holtzman, Roi Dagan, William M Mendenhall

Journal: Oral and maxillofacial surgery clinics of North America 2023;35(3):469-484

PMID: 37005171

Full Text on Elsevier Science View on PubMed

Abstract

Proton therapy (PT) is a form of highly conformal external-beam radiotherapy used to mitigate acute and late effects following radiotherapy. Indications for treatment include both benign and malignant skull-base and central nervous system pathologies. Studies have demonstrated that PT shows promising results in minimizing neurocognitive decline and reducing second malignancies with low rates of central nervous system necrosis. Future directions and advances in biologic optimization may provide additional benefits beyond the physical properties of particle dosimetry.

Address: Department of Radiation Oncology, University of Florida College of Medicine, 2015 North Jefferson Street, Jacksonville, FL 32206, USA. Electronic address: [email protected].; Department of Radiation Oncology, University of Florida College of Medicine, 2015 North Jefferson Street, Jacksonville, FL 32206, USA.

DOI: 10.1016/j.coms.2023.02.003

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Protons, Skull Base Neoplasms, Proton Therapy, Diagnostic Imaging, Skull, Radiotherapy Dosage