Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review.

Changhui Zhu, Chunyan Liu, Zhengbin Chai

Journal: Frontiers in immunology 2023;14():1115794

PMID: 37020554

Free Full Text on PubMed Central View on PubMed

Abstract

The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research.

Address: Department of Plastic Surgery, Shandong Provincial Qianfoshan Hospital, School of Basic Medical Sciences, Weifang Medical University, Weifang, Shandong, China.; Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.; Department of Clinical Laboratory Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, China.

DOI: 10.3389/fimmu.2023.1115794

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/autoimmunediseases.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-68

MeSH Terms: Humans, Protein-Arginine Deiminases, Isoenzymes, Autoimmune Diseases, Histones, Neoplasms