A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.

Luca Laghi, Eva Román, Qiuyu Lan, Juan Camilo Nieto, Aleix Canalda-Baltrons, Maria Poca, Maria B Sánchez-Rodríguez, Joan Clària, Edilmar Alvarado, Berta Cuyàs, Elisabet Sánchez, Sílvia Vidal, Carlos Guarner, Àngels Escorsell, Chaysavanh Manichanh, German Soriano

Journal: Hepatology communications 2023;7(4):e0072

PMID: 37026745

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Abstract

To explore the potential mechanisms underlying the effects of a probiotic in cirrhotic patients, we analyzed the blood metabolome using proton nuclear magnetic resonance (1H-NMR) spectroscopy in 32 patients with cirrhosis and cognitive dysfunction or falls. Patients were randomized to receive a multistrain probiotic or placebo for 12 weeks. Among the 54 metabolites identified, the only significant changes in the probiotic group were an increase in glutamine, a decrease in glutamate, and an increase in the glutamine/glutamate ratio. In the placebo group, glutamate increased and the glutamine/glutamate ratio decreased. Our results suggest the multistrain probiotic could influence glutamine/glutamate metabolism, increasing the capacity of ammonia detoxification.

Address: Department of Agricultural and Food Sciences, University of Bologna, Cesena, Italy.; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Escola Universitària d'Infermeria EUI-Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.; Institut de Recerca IIB-Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.; Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.; European Foundation for the Study of Chronic Liver Failure (EF Clif), Barcelona, Spain.; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

DOI: 10.1097/HC9.0000000000000072

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MeSH Terms: Humans, Glutamine, Glutamic Acid, Metabolomics, Liver Cirrhosis, Probiotics