Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication.

Marat G Uzbekov

Journal: Biochemistry. Biokhimiia 2023;88(4):491-501

PMID: 37080935

Abstract

["The review describes the syndrome of endogenous intoxication in patients with mental disorders. Oxidative stress, middle-mass endotoxic molecules, impaired functional properties of serum albumin and albumin thiol groups, neurotrophic factors, and enzymes, including monoamine oxidase and semicarbazide-sensitive amine oxidase contribute to the development of endogenous intoxication. Possible pathogenetic mechanisms of the endogenous intoxication development in mental disorders and approaches to its treatment are discussed."]
Address: Moscow Research Institute of Psychiatry, Serbsky National Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, 107258, Russia. [email protected].

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