Sorting nexins: role in the regulation of blood pressure.

Juan Huang, Andrew C Tiu, Pedro A Jose, Jian Yang

Journal: The FEBS journal 2023;290(3):600-619

PMID: 34847291

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Abstract

Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure via several mechanisms. Aberrant expression and dysfunction of SNXs participate in the dysregulation of blood pressure. Genetic studies show a correlation between SNX gene variants and the response to antihypertensive drugs. In this review, we summarize the progress in SNX-mediated regulation of blood pressure, discuss the potential role of SNXs in the pathophysiology and treatment of hypertension, and propose novel strategies for the medical therapy of hypertension.

Address: Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Medicine, Einstein Medical Center Philadelphia, PA, USA.; Division of Renal Diseases & Hypertension, Department of Medicine, The George Washington University School of Medicine & Health Sciences, DC, USA.; Department of Physiology and Pharmacology, The George Washington University School of Medicine & Health Sciences, DC, USA.

DOI: 10.1111/febs.16305

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MeSH Terms: Sorting Nexins, Blood Pressure, Signal Transduction, Endosomes, Protein Transport