The effects of (Poaceae family) and (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial.

OBJECTIVES

Given high and growing prevalence rate of urolithiasis in most societies as well as the problems caused by this issue, it is necessary to apply more cost-effective and safer therapeutic methods, which are accessible for all the individuals worldwide. Therefore, this study aimed to investigate efficacy of herbal medicines named and on solving and excretion of renal and urinary tract stones in patients with urolithiasis.

METHODS

This study included 96 patients with urolithiasis who were randomly allocated into three groups. The first group received the extract of seeds (1,600 mg), the second group received extract of rhizome (1,600 mg) and the third group received placebo for 21 days. In this study, we used an hydroalcoholic extract of and prepared by Soxhlet method. For each patient, the size of the stones, the amount of calcium in the urine, the number of stones excreted and their chemical substance type were measured.

RESULTS

In this study, changes were observed at the significance level in the interventions groups of 1 and 2, and the placebo group in the left kidney, so that changes in size of the stone in left kidney as intergroup were significantly different in these three groups (p=0.02). The mean of changes in stone size in left kidney in the group was 3.78 ± 7.1 and in the group , it was 0.27 ± 0.6.

CONCLUSIONS

A significant difference in the results of this study show that rhizome and seed extracts are able to decrease the size of the stone and can be effective on kidney stones excretion.

© 2022 Walter de Gruyter GmbH, Berlin/Boston.