Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue.

François Zimmermann, François Robin, Leila Caillault, Claire Cazalets, Francisco Llamas-Gutierrez, Ronan Garlantézec, Sandrine Jousse-Joulin, Elisabeth Diot, Sami Eric Mensi, Nicolas Belhomme, Patrick Jégo, Guillaume Coiffier, Alain Lescoat

Journal: Rheumatology (Oxford, England) 2023;62(SI):SI1-SI11

PMID: 35866609

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Abstract

SSc is an auto-immune disease characterized by life-threatening manifestations such as lung fibrosis or pulmonary arterial hypertension. Symptoms with a detrimental impact on quality of life are also reported and sicca syndrome (xerostomia, xeropthalmia) is present in up to 80% of patients with SSc. Sicca syndrome can occur in the absence of overlap with Sjögren's disease and recent studies highlight that fibrosis of minor and major salivary glands, directly linked to the pathogenesis of SSc, could be a major contributor of xerostomia in SSc. This narrative review provides an overview of the clinical presentation, diagnostic strategies, management and future perspectives on sicca syndrome in patients with SSc.

Address: Department of Internal Medicine.; Department of Rheumatology, CHU Rennes, University of Rennes 1.; Department of Rheumatology, Rennes University Hospital, University Rennes; Inserm UMR 1241, Inra, Institut NUMECAN (Nutrition Metabolisms and Cancer), University Rennes.; Department of Anatomopathology, CHU Rennes, University of Rennes 1.; Département de Santé Publique, CHU de Rennes, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, Rennes.; Rheumatology Department, CHU de Brest, Univ Brest, Inserm, LBAI, UMR1227, Brest.; Department of Internal Medicine, CHRU Tours, Tours.; Department of Internal Medicine.; Département de Santé Publique, CHU de Rennes, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, Rennes.; Department of Internal Medicine.; Department of Rheumatology, CH Dinan, Dinan, France.

DOI: 10.1093/rheumatology/keac412

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MeSH Terms: Humans, Sjogren's Syndrome, Quality of Life, Scleroderma, Systemic, Xerostomia, Salivary Glands