Serum concentrations of ketones increase after hand-ergometer exercise in persons with cervical spinal cord injuries: a preliminary prospective study.

Kazunari Nishiyama, Yukihide Nishimuara, Jason S Au, Yoshi-Ichiro Kamijo, Takashi Moriki, Yuki Mukai, Yasunori Umemoto, Ken Kouda, Takahiro Ogawa, Fumihiro Tajima

Journal: Spinal cord 2023;61(2):139-144

PMID: 36241700

Full Text on Nature Publishing Group View on PubMed

Abstract

STUDY DESIGN

Experimental study.

OBJECTIVES

To compare lipid profiles during moderate-intensity exercise between persons with cervical spinal cord injuries (SCI) and able-bodied controls (AB).

SETTING

Wakayama Medical University, Japan.

METHODS

Six participants with SCI and six AB performed 30-min arm-crank exercise at 50% VO. Blood samples were collected before (PRE), immediately (POST), and 60 min after exercise (REC). Concentrations of serum free fatty acids ([FFA]), total ketone bodies ([tKB]), acetoacetic acid ([AcAc]), insulin ([Ins]), and plasma catecholamines and glucose ([Glc]) were assessed.

RESULTS

Catecholamine concentrations in SCI were lower than AB throughout the experiment (P < 0.001) and remained unchanged, while increased at POST in AB (P < 0.01). [FFA] remained unchanged in both groups with no differences between groups. [tKB] in SCI tended to increase at REC from PRE (P = 0.043), while remaining unchanged in AB (P > 0.42). [AcAc] in SCI increased at REC from PRE and POST (P < 0.01) while remaining unchanged in AB (interactions of Group × Time P = 0.014). [Glc] and [Ins] were comparable between the groups throughout the study.

CONCLUSION

Serum ketone bodies in SCI increased after exercise while remaining unchanged in AB, suggesting that suppressed uptakes of serum ketone bodies from blood to the muscles in SCI would partially contribute the increased serum ketones.

Address: Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan.; Department of Rehabilitation Medicine, Iwate Medical University, Yahaba-cho, 028-3695, Japan.; Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan. [email protected].; Department of Rehabilitation Medicine, Iwate Medical University, Yahaba-cho, 028-3695, Japan. [email protected].; Medical Center for Health Promotion and Sports Science, Wakayama Medical University, Wakayama, 640-8033, Japan. [email protected].; Medical Center for Health Promotion and Sports Science, Wakayama Medical University, Wakayama, 640-8033, Japan.; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan.; Medical Center for Health Promotion and Sports Science, Wakayama Medical University, Wakayama, 640-8033, Japan.; Department of Rehabilitation Medicine, Dokkyo Medical University Saitama Medical Center, Koshigaya, 343-8555, Japan.; Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan.; Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan.; Medical Center for Health Promotion and Sports Science, Wakayama Medical University, Wakayama, 640-8033, Japan.; Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan.; Chuzan Hospital Clinical Education and Research Center, Okinawa, 904-2151, Japan.; Department of Rehabilitation Medicine, Aichi Medical University, Aichi, 480-1195, Japan.

DOI: 10.1038/s41393-022-00859-x

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Full Text Sources:

https://doi.org/10.1038/s41393-022-00859-x

MeSH Terms: Humans, Spinal Cord Injuries, Prospective Studies, Ketones, Cervical Cord, Ketone Bodies, Catecholamines