Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications.

Address: Translational Gastroenterology Unit, Experimental Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.; Department of Gastroenterology, National Children's Medical Center, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.; SenTcell Ltd., London, UK.; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Gene Center, LMU Munich, Munich, Germany.; Deutsche Zentrum für Infektionsforschung (DZIF) and Deutsches Zentrum für Kinder- und Jugendgesundheit, Partner site Munich, Munich, Germany.; SickKids Inflammatory Bowel Disease Centre and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Toronto, Canada.; The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.; Centre of Medicines Discovery, NDM, University of Oxford, Oxford, OX3 7DQ, UK.; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, OX3 7FY, UK.; Department of Gastroenterology, National Children's Medical Center, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. [email protected].; Translational Gastroenterology Unit, Experimental Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK. [email protected].; Department of Pediatrics, University of Oxford, Oxford, UK. [email protected].; Biomedical Research Center, University of Oxford, Oxford, UK. [email protected].