Role of Lipoprotein Levels and Function in Atherosclerosis Associated with Autoimmune Rheumatic Diseases.

Nicoletta Ronda, Francesca Zimetti, Maria Pia Adorni, Marcella Palumbo, George A Karpouzas, Franco Bernini

Journal: Rheumatic diseases clinics of North America 2022;49(1):151-163

PMID: 36424022

Full Text on Elsevier Science View on PubMed

Abstract

Immune and inflammatory mediators in autoimmune rheumatic diseases induce modification in the activity of enzymes pivotal for lipid metabolism and promote a proatherogenic serum lipid profile. However, disturbances in low- and high-density lipoprotein composition and increased lipid oxidation also occur. Therefore, lipoprotein dysfunction causes intracellular cholesterol accumulation in macrophages, smooth muscle cells, and platelets. Overall, both plaque progression and acute cardiovascular events are promoted. Single rheumatic diseases may present a particular pattern of lipid disturbances so that standard methods to evaluate cardiovascular risk may not be accurate enough. In general, antirheumatic drugs positively affect lipid metabolism in these patients.

Address: Department of Food and Drug, University of Parma, Parco Area delle Scienze, 27/A, Parma 43124, Italy. Electronic address: [email protected].; Department of Food and Drug, University of Parma, Parco Area delle Scienze, 27/A, Parma 43124, Italy.; Department of Medicine and Surgery, Unit of Neuroscience, University of Parma, Via Volturno 39/F, Parma 43125, Italy.; Division of Rheumatology, Harbor-UCLA Medical Center and the Lundquist Institute, Torrance, CA, USA.

DOI: 10.1016/j.rdc.2022.07.006

Link outs

Free resources

Medical:

https://medlineplus.gov/atherosclerosis.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Lipoproteins, Atherosclerosis, Autoimmune Diseases, Rheumatic Diseases, Antirheumatic Agents