Cognitive decline and dementia in women after menopause: Prevention strategies.

Bogdan Stefanowski, Marek Kucharski, Anna Szeliga, Milena Snopek, Anna Kostrzak, Roman Smolarczyk, Marzena Maciejewska-Jeske, Anna Duszewska, Olga Niwczyk, Slawomir Drozd, Monika Englert-Golon, Katarzyna Smolarczyk, Blazej Meczekalski

Journal: Maturitas 2023;168():53-61

PMID: 36493633

Full Text on Elsevier Science View on PubMed

Abstract

Worldwide, cognitive decline and dementia are becoming one of the biggest challenges for public health. The decline in cognition and the development of dementia may be caused by predisposing or trigger factors. There is no consensus over whether the drop in estrogen levels after menopause is a risk factor for cognitive decline and dementia. This article discusses the prevention of cognitive decline and dementia in women after menopause, both primary prevention (essentially pharmacological intervention) and secondary prevention (chiefly diet and weight reduction). Further study is required to clarify whether menopausal hormone therapy (MHT) has a role in dementia.

Address: First Department of Psychiatry, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland.; Department of Gynecological Endocrinology, Warsaw Medical University, 00-315 Warsaw, Poland.; Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.; Division of Histology and Embryology, Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences Warsaw, Poland.; College of Medical Sciences, Institute of Physical Culture Studies, University of Rzeszow, Poland.; Surgical Gynecology Clinic, Department of Gynaecology Obstetrics and Gynaecological Oncology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.; Department of Dermatology Immunodermatology and Venereology, Medical University of Warsaw, Warsaw, Poland. Electronic address: [email protected].; Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland. Electronic address: [email protected].

DOI: 10.1016/j.maturitas.2022.10.012

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MeSH Terms: Female, Humans, Estrogen Replacement Therapy, Menopause, Cognitive Dysfunction, Estrogens, Dementia