Medicinal chemistry insights into antiviral peptidomimetics.

Dang Ding, Shujing Xu, Edeildo Ferreira da Silva-Júnior, Xinyong Liu, Peng Zhan

Journal: Drug discovery today 2023;28(3):103468

PMID: 36528280

Full Text on Elsevier Science View on PubMed

Abstract

The (re)emergence of multidrug-resistant viruses and the emergence of new viruses highlight the urgent and ongoing need for new antiviral agents. The use of peptidomimetics as therapeutic drugs has often been associated with advantages, such as enhanced binding affinity, improved metabolic stability, and good bioavailability profiles. The development of novel antivirals is currently driven by strategies of converting peptides into peptidomimetic derivatives. In this review, we outline different structural modification design strategies for developing novel peptidomimetics as antivirals, involving N- or C-cap terminal structure modifications, pseudopeptides, amino acid modifications, inverse-peptides, cyclization, and molecular hybridization. We also present successful recent examples of peptidomimetic designs.

Address: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China.; Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil.; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China. Electronic address: [email protected].; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China. Electronic address: [email protected].

DOI: 10.1016/j.drudis.2022.103468

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/CPTAC-325

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1359...

MeSH Terms: Peptidomimetics, Antiviral Agents, Chemistry, Pharmaceutical, Peptides