Biosystem design of Corynebacterium glutamicum for bioproduction.

Jian Zha, Zhen Zhao, Zhengyang Xiao, Thomas Eng, Aindrila Mukhopadhyay, Mattheos Ag Koffas, Yinjie J Tang

Journal: Current opinion in biotechnology 2023;79():102870

PMID: 36549106

Free Full Text on eScholarship, University of California - Access Free Full Text View on PubMed

Abstract

Corynebacterium glutamicum, a natural glutamate-producing bacterium adopted for industrial production of amino acids, has been extensively explored recently for high-level biosynthesis of amino acid derivatives, bulk chemicals such as organic acids and short-chain alcohols, aromatics, and natural products, including polyphenols and terpenoids. Here, we review the recent advances with a focus on biosystem design principles, metabolic characterization and modeling, omics analysis, utilization of nonmodel feedstock, emerging CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) tools for Corynebacterium strain engineering, biosensors, and novel strains of C. glutamicum. Future research directions for developing C. glutamicum cell factories are also discussed.

Address: School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi 710021, China.; Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, MO 63130, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.; Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, MO 63130, USA. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2022.102870

Link outs

Free resources

Full Text Sources:

https://escholarship.org/uc/item/qt75g874b4

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

MeSH Terms: Corynebacterium glutamicum, Metabolic Engineering, Amino Acids, Clustered Regularly Interspaced Short Palindromic Repeats, Biological Products