Review on the genus Polygonatum polysaccharides: Extraction, purification, structural characteristics and bioactivities.

Huan Gong, Xiaona Gan, Yingzhe Li, Jie Chen, Yongbin Xu, Songshan Shi, Tingzhao Li, Bo Li, Huijun Wang, Shunchun Wang

Journal: International journal of biological macromolecules 2023;229():909-930

PMID: 36608864

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Abstract

The genus Polygonatum is gaining increasing attention from nutrition experts as well as health-conscious consumers because of its excellent performance in providing nutrients. Among these plants, Polygonatum sibiricum and Polygonatum odoratum have been selected for inclusion in China's Medicinal Food Directory due to their high safety profile. Polysaccharides are considered the main functional component and one of the main active ingredients of the plant. In addition, polysaccharides from genus Polygonatum have a variety of nutritional, biological and health-promoting properties, such as immunomodulatory, anti-inflammatory, cardiovascular protective, neuroprotective, antitumor, antidiabetic, antiosteoporosis, and hepatoprotective properties. This paper reviews the origin, extraction, purification, structural characteristics, biological activity, safety, toxicological evaluation, and structure-activity relationship of polysaccharides from the genus Polygonatum. Ultimately, we hope that this work can provide a more useful reference for understanding the polysaccharide structure and developing of new functional foods from polysaccharides of the genus Polygonatum.

Address: The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Amway Innovation & Science (Shanghai), 720 Cailun Road, Shanghai 201203, China.; Amway Innovation & Science (Shanghai), 720 Cailun Road, Shanghai 201203, China. Electronic address: [email protected].; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: [email protected].; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: [email protected].

DOI: 10.1016/j.ijbiomac.2022.12.320

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MeSH Terms: Polygonatum, Polysaccharides, Antioxidants, Immunomodulation, Hypoglycemic Agents