The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.

Paul F Fitzpatrick

Journal: Archives of biochemistry and biophysics 2023;735():109518

PMID: 36639008

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Abstract

The aromatic amino acid hydroxylases phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase are non-heme iron enzymes that catalyze key physiological reactions. This review discusses the present understanding of the common catalytic mechanism of these enzymes and recent advances in understanding the relationship between their structures and their regulation.

Address: Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, 78229, USA. Electronic address: [email protected].

DOI: 10.1016/j.abb.2023.109518

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MeSH Terms: Mixed Function Oxygenases, Tryptophan Hydroxylase, Tyrosine 3-Monooxygenase, Phenylalanine Hydroxylase, Amino Acids, Aromatic, Catalysis