Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies.

Hanchao Lin, Yixin Yu, Le Zhu, Nannan Lai, Luming Zhang, Yu Guo, Xinxin Lin, Dongqin Yang, Ning Ren, Zhiling Zhu, Qiongzhu Dong

Journal: Redox biology 2023;59():102601

PMID: 36630819

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Abstract

Hydrogen sulfide (HS) is an important signaling molecule in colorectal cancer (CRC). It is produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and the release of intestinal microbes, and is oxidatively metabolized in the colonocytes' mitochondria. Both endogenous HS in colonic epithelial cells and exogenous HS in intestinal lumen contribute to the onset and progression of CRC. The up-regulation of endogenous synthetases is thought to be the cause of the elevated HS levels in CRC cells. Different diagnostic probes and combination therapies, as well as tumor treatment approaches through HS modulation, have been developed in recent years and have become active area of investigation for the diagnosis and treatment of CRC. In this review, we focus on the specific mechanisms of HS production and oxidative metabolism as well as the function of HS in the occurrence, progression, diagnosis, and treatment of CRC. We also discuss the present challenges and provide insights into the future research of this burgeoning field.

Address: Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, China; Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, China.; College of Materials Science and Engineering, Qingdao University of Science and Technology, China.; Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, China.; Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, China.; Department of Digestive Diseases, Huashan Hospital, Fudan University, China. Electronic address: [email protected].; Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, China; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, And Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, China. Electronic address: [email protected].; College of Materials Science and Engineering, Qingdao University of Science and Technology, China. Electronic address: [email protected].; Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, China. Electronic address: [email protected].

DOI: 10.1016/j.redox.2023.102601

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https://medlineplus.gov/colorectalcancer.html

MeSH Terms: Humans, Hydrogen Sulfide, Mitochondria, Colorectal Neoplasms