Role of organellar Ca2+-activated K+ channels in disease development.

The organellar Ca-activated K channels share a similar ability to transfer the alteration of Ca concentration to membrane conductance of potassium. Multiple effects of Ca-activated K channels on cell metabolism and complex signaling pathways during organ development have been explored. The organellar Ca-activated K channels are able to control the ionic equilibrium and are always associated with oxidative stress in different organelles and the whole cells. Some drugs targeting Ca-activated K channels have been tested for various diseases in clinical trials. In this review, the known roles of organellar Ca-activated K channels were described, and their effects on different diseases, particularly on diabetes, cardiovascular diseases, and neurological diseases were discussed. It was attempted to summarize the currently known operational modes with the involvement of organellar Ca-activated K channels. This review may assist scholars to more comprehensively understand organellar Ca-activated K channels and related diseases.

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