Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo.

Address: Laboratories of Immunology and Antibody Glycan Analysis, Institute of Nutritional Medicine, University of Lübeck and University Hospital Schleswig-Holstein, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Lübeck, Germany.; Core Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.; Division of Clinical and Molecular Allergology, Priority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, Germany.; Fraunhofer Institute of Toxicology and Experimental Medicine, German Center for Lung Research (DZL), Hannover, Germany.; Department of Human Medicine, Medical School Berlin, Berlin, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Interdisciplinary Allergy Outpatient Clinic, Department of Pneumology, University of Lübeck, Lübeck, Germany.; Department of Anesthesiology and Intensive Care, University of Lübeck and University Medical Center of Schleswig-Holstein, Lübeck, Germany.