Deciphering the role of Hippo pathway in lung cancer.

Soudeh Ghafouri-Fard, Yadollah Poornajaf, Bashdar Mahmud Hussen, Shiva Tavakkoli Avval, Mohammad Taheri, Majid Mokhtari

Journal: Pathology, research and practice 2023;243():154339

PMID: 36736143

Full Text on Elsevier Science View on PubMed

Abstract

Hippo pathway has been initially recognized as a regulatory mechanism for modulation of organ size in fruitfly. Subsequently, its involvement in the regulation of homeostasis and tumorigenesis has been identified. This pathway contains some tumor suppressor genes such as hippo (hpo) and warts (wts), as well as a number of oncogenic ones such as yorkie (yki). Recent studies have shown participation of Hippo pathway in the lung carcinogenesis. This pathway can affect lung cancer via different mechanisms. The interaction between some miRNAs and Hippo pathway is a possible mechanism for carcinogenic processes. Moreover, some other types of non-coding RNAs including PVT1, SFTA1P, NSCLCAT1 and circ_0067741 are implicated in this process. Besides, anti-cancer effects of gallic acid, icotinib hydrochloride, curcumin, ginsenoside Rg3, cryptotanshinone, nitidine chloride, cucurbitacin E, erlotinib, verteporfin, sophoridine, cisplatin and verteporfin in lung cancer are mediated through modulation of Hippo pathway. Here, we summarize the results of recent studies that investigated the role of Hippo signaling in the progression of lung cancer, the impact of non-coding RNAs on this pathway and the effects of anti-cancer agents on Hippo signaling in the context of lung cancer.

Address: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.; Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.; Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.prp.2023.154339

Link outs

Free resources

Medical:

https://medlineplus.gov/lungcancer.html

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0344...

MeSH Terms: Humans, Hippo Signaling Pathway, Signal Transduction, Protein Serine-Threonine Kinases, Verteporfin, Drosophila Proteins, Lung Neoplasms