Synbiotic supplement for treatment of iron deficiency anaemia in haemodialysis patients: A randomized controlled trial.

Akram Kooshki, Roya Akbarzadeh, Bahareh Amin, Tahereh Tofighiyan, Elaheh Foroumandi

Journal: Nephrology (Carlton, Vic.) 2023;28(4):234-239

PMID: 36745046

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Abstract

BACKGROUND

There is evidence that probiotics can increase the availability of iron. The aim of current study was to determine the effects of synbiotic supplementation on the haematological parameters and anaemia in haemodialysis patients.

METHODS

This study was a randomized, double-blind, placebo-controlled trial. Fifty patients were randomly selected from the haemodialysis section of Vaseii Hospital, Sabzevar, Iran. Subjects in the symbiotic and control groups received 2 capsules of synbiotic supplement or placebo, respectively, once a day for 8 weeks. Blood samples were divided into two test tubes in equal volumes. Blood haemoglobin, haematocrit, transferrin saturation, red blood cells (RBCs), and total iron binding capacity (TIBC) were measured with auto-analyser. Ferritin was determined using Sandwich enzyme-linked immunosorbent assay (ELISA).

RESULTS

Twenty tree patients in each group completed the study. Significant results were recorded in synbiotic groups regarding the concentration of blood haemoglobin, haematocrit, transferrin saturation, the number of RBCs, and serum ferritin compare to placebo group (P < .05). At the end of week 8, TIBC significantly decreased in synbiotic than placebo group (P < .05).

CONCLUSION

Synbiotic supplementation could be a safe and promising candidate in improving anaemia in CKD patients.

Address: Non-Communicable Disease Research Center, Department of Nutrition & Biochemistry, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Department of Anesthesia & Operating Room, School of Paramedic, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Department of Nursing, School of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran.

DOI: 10.1111/nep.14149

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MeSH Terms: Humans, Anemia, Iron-Deficiency, Synbiotics, Iron, Ferritins, Anemia, Hemoglobins, Renal Dialysis, Transferrins, Double-Blind Method