A review on the role of ADAMTS9-AS2 in different disorders.

Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Majid Mokhtari

Journal: Pathology, research and practice 2023;243():154346

PMID: 36746036

Full Text on Elsevier Science View on PubMed

Abstract

Recent decade has seen a tremendous progress in identification of the role of different long non-coding RNAs (lncRNAs) in human pathologies. ADAMTS9-AS2 is an example of lncRNAs with different roles in human disorders. It is mostly acknowledged as a tumor suppressor lncRNA in different types of cancers. However, it has been reported to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma and glioblastoma. Moreover, ADAMTS9-AS2 is possibly involved in the pathoetiology of pulpitis, acute ischemic stroke, type 2 diabetes and its complications. This lncRNA sponges miR-196b-5p, miR-223-3p, miR-130a-5p, miR-600, miR-223-3p, miR-27a-3p, miR-32, miR-143-3p, miR-143-3p and miR-182-5p in order to regulate downstream mRNAs. This review aims at summarization of the role of ADAMTS9-AS2 in different disorders with a particular focus on its diagnostic and prognostic values.

Address: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.; Institute of Human Genetics, Jena University Hospital, Jena, Germany.; Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.prp.2023.154346

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MeSH Terms: Humans, MicroRNAs, RNA, Long Noncoding, Carcinoma, Squamous Cell, Diabetes Mellitus, Type 2, Ischemic Stroke, Tongue Neoplasms, Cell Proliferation, ADAMTS9 Protein