Phytochemistry and pharmacology of Armeniacae semen Amarum: A review.

Yumin Wei, Yanan Li, Shengguang Wang, Zedong Xiang, Xiaoyu Li, Qingquan Wang, Weichao Dong, Peng Gao, Long Dai

Journal: Journal of ethnopharmacology 2023;308():116265

PMID: 36806484

Full Text on Elsevier Science View on PubMed

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Armeniacae Semen Amarum (Prunus armeniaca L. var. ansu Maxim., Ku xingren, bitter almond, ASA) is an important medicine in Traditional Chinese Medicine (TCM). It is widely used because of its remarkable curative effect in relieving cough and asthma, moistening intestines and defecating.

AIM OF THE REVIEW

This review aims to enlighten the deeper knowledge about ASA, giving a comprehensive overview of its traditional uses, phytochemistry, pharmacology and toxicology for future investigation of plant-based drugs and therapeutic applications.

MATERIALS AND METHODS

The databases used are Web of Science, PubMed, Baidu academic, Google academic, CNKI, Wanfang and VIP . In addition, detailed information on ASA was obtained from relevant monographs such as Chinese Pharmacopoeia.

RESULTS

The active components of ASA mainly include amygdalin, bitter almond oil, essential oil, protein, vitamin, trace elements and carbohydrates. The pharmacological studies have shown that ASA has beneficial effects such as antitussive, antiasthmatic, anti-inflammatory, analgesic, antioxidant, antitumour, cardioprotective, antifibrotic, immune regulatory, bowel relaxation, insecticidal, etc. CONCLUSIONS: Many reports have been published on ASA's various active ingredients and biological uses. However, only a few reviews on its phytoconstituents and pharmacological uses. In addition, the exploration and development of ASA in other fields also deserve more attention in future research.

Address: School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: [email protected].; School of Pharmacy, Binzhou Medical University, Yantai, 264003, China. Electronic address: [email protected].

DOI: 10.1016/j.jep.2023.116265

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MeSH Terms: Seeds, Drugs, Chinese Herbal, Medicine, Chinese Traditional, Amygdalin, Phytochemicals, Ethnopharmacology