Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis.

Yu-Han Gao, Xing Li

Journal: Neurochemistry international 2023;164():105501

PMID: 36803679

Full Text on Elsevier Science View on PubMed

Abstract

Growing evidence points to the importance of cholesterol in preserving brain homeostasis. Cholesterol makes up the main component of myelin in the brain, and myelin integrity is vital in demyelinating diseases such as multiple sclerosis. Because of the connection between myelin and cholesterol, the interest in cholesterol in the central nervous system increased during the last decade. In this review, we provide a detailed overview on brain cholesterol metabolism in multiple sclerosis and its role in promoting oligodendrocyte precursor cell differentiation and remyelination.

Address: National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710119, China.; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710119, China. Electronic address: [email protected].

DOI: 10.1016/j.neuint.2023.105501

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MeSH Terms: Humans, Multiple Sclerosis, Myelin Sheath, Central Nervous System, Oligodendroglia, Brain, Cell Differentiation