The emerging crosstalk between atherosclerosis-related microRNAs and Bermuda triangle of foam cells: Cholesterol influx, trafficking, and efflux.

Harun Achmad, Yasir Q Almajidi, Hussein Adel, Rasha Fadhel Obaid, Rosario Mireya Romero-Parra, Wesam R Kadhum, Abbas F Almulla, Firas Rahi Alhachami, Gamal A Gabr, Yasser Fakri Mustafa, Reza Mahmoudi, Seyedreza Hosseini-Fard

Journal: Cellular signalling 2023;106():110632

PMID: 36805844

Full Text on Elsevier Science View on PubMed

Abstract

In atherosclerosis, the gradual buildup of lipid particles into the sub-endothelium of damaged arteries leads to numerous lipid alterations. The absorption of these modified lipids by monocyte-derived macrophages in the arterial wall leads to cholesterol accumulation and increases the likelihood of foam cell formation and fatty streak, which is an early characteristic of atherosclerosis. Foam cell formation is related to an imbalance in cholesterol influx, trafficking, and efflux. The formation of foam cells is heavily regulated by various mechanisms, among them, the role of epigenetic factors like microRNA alteration in the formation of foam cells has been well studied. Recent studies have focused on the potential interplay between microRNAs and foam cell formation in the pathogenesis of atherosclerosis; nevertheless, there is significant space to progress in this attractive field. This review has focused to examine the underlying processes of foam cell formation and microRNA crosstalk to provide a deep insight into therapeutic implications in atherosclerosis.

Address: Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Indonesia.; Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq.; Al-Farahidi University, College of Dentistry, Baghdad, Iraq.; Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq.; Universidad Continental, Lima, Peru.; Department of Pharmacy, Kut University College, Kut 52001, Wasit, Iraq.; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.; Radiology Department, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.; Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center, Giza, Egypt.; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.cellsig.2023.110632

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MeSH Terms: Humans, Foam Cells, MicroRNAs, Cholesterol, Atherosclerosis, Macrophages