Treatment of oropharyngeal squamous cell carcinoma: Is swallowing quality better after TORS or RT?

Flaminia Campo, Oreste Iocca, Armando De Virgilio, Francesco Mazzola, Giuseppe Mercante, Barbara Pichi, Floyd Christopher Holsinger, Pasquale Di Maio, Sara Ramella, Raul Pellini

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2023;183():109547

PMID: 36813176

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND AND PURPOSE

To answer an important question regarding the long-term morbidity of two oncological equivalent treatment for oropharyngeal squamous cell carcinoma (OPSCC), namely a comparison of swallowing function results between patients treated with trans-oral robotic surgery (TORS) versus patients treated with radiotherapy (RT).

MATERIALS AND METHODS

Studies included patients with OPSCC treated with TORS or RT. Articles reporting complete data on MD Anderson Dysphagia Inventory (MDADI) and comparing the two treatments (TORS vs RT) were included in the meta-analysis. Swallowing assessed with MDADI was the primary outcome, the evaluation with instrumental methods was the secondary aim.

RESULTS

Included studies provided a total of 196 OPSCC primarily treated with TORS vs 283 OPSCC primarily treated with RT. The mean difference in MDADI score at the longest follow-up was not significantly different between TORS and RT group (mean difference [MD] -0.52; 95% CI -4.53-3.48; p = 0.80). After treatment, mean composite MDADI scores demonstrated a slight impairment in both groups without reaching a statistical difference compared to the baseline status. DIGEST score and Yale score showed a significantly worse function in both treatment groups at 12-month follow-up compared to baseline status.

CONCLUSION

The meta-analysis demonstrates that up-front TORS (+- adjuvant therapy) and up-front RT (+- CT) appear to be equivalent treatments in functional outcomes in T1-T2, N0-2 OPSCC, however, both treatments cause impaired swallowing ability. Clinicians should have a holistic approach and work with patients to develop an individualized nutrition plan and swallowing rehabilitation protocol from diagnosis to post-treatment surveillance.

Address: Department of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy; Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00186 Rome, Italy. Electronic address: [email protected].; Division of Maxillofacial Surgery, Surgical Science Department, University of Torino, Torino, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy; Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.; Department of Otolaryngology - Head and Neck Surgery, Stanford University Medical Center, Palo Alto, CA, USA.; Department of Otoralyngology-head and Neck Surgery, Giuseppe Fornaroli Hospital, ASST Ovest Milanese, Magenta-Milan, Italy.; Radiation Oncology, Campus Bio-Medico University Hospital Foundation, Rome, Italy.

DOI: 10.1016/j.radonc.2023.109547

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MeSH Terms: Humans, Squamous Cell Carcinoma of Head and Neck, Deglutition, Oropharyngeal Neoplasms, Robotic Surgical Procedures, Head and Neck Neoplasms