Protein-protein interaction and interference of carcinogenesis by supramolecular modifications.

Oluwatosin A Saibu, Sodiq O Hammed, Oladapo O Oladipo, Tope T Odunitan, Temitope M Ajayi, Aderonke J Adejuyigbe, Boluwatife T Apanisile, Oluwatoba E Oyeneyin, Adenrele T Oluwafemi, Tolulope Ayoola, Olamide T Olaoba, Abdullahi O Alausa, Damilola A Omoboyowa

Journal: Bioorganic & medicinal chemistry 2023;81():117211

PMID: 36809721

Full Text on Elsevier Science View on PubMed

Abstract

Protein-protein interactions (PPIs) are essential in normal biological processes, but they can become disrupted or imbalanced in cancer. Various technological advancements have led to an increase in the number of PPI inhibitors, which target hubs in cancer cell's protein networks. However, it remains difficult to develop PPI inhibitors with desired potency and specificity. Supramolecular chemistry has only lately become recognized as a promising method to modify protein activities. In this review, we highlight recent advances in the use of supramolecular modification approaches in cancer therapy. We make special note of efforts to apply supramolecular modifications, such as molecular tweezers, to targeting the nuclear export signal (NES), which can be used to attenuate signaling processes in carcinogenesis. Finally, we discuss the strengths and weaknesses of using supramolecular approaches to targeting PPIs.

Address: Department of Environmental Toxicology, Universitat Duisburg-Essen, NorthRhine-Westphalia, Germany.; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo State, Nigeria; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. Electronic address: [email protected].; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo State, Nigeria; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Nutrition and Dietetics, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Theoretical and Computational Chemistry Unit, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria.; Department of Molecular Pathogenesis and Therapeutics, University of Missouri-Columbia, Columbia, MO 65211, USA.; Department of Molecular Biology and Biotechnology, ITMO University, St Petersburg, Russia.; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria.

DOI: 10.1016/j.bmc.2023.117211

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MeSH Terms: Humans, Proteins, Neoplasms, Carcinogenesis