Restless legs syndrome and periodic limb movements of sleep: fact, fad, and fiction.

Sanjiv Patel

Journal: Current opinion in pulmonary medicine 2002;8(6):498-501

PMID: 12394156

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Abstract

Restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) are common disorders seen in sleep disorder centers. Although RLS in universally thought to cause daytime sleepiness, the role of PLMS in causing sleepiness (or any symptom!) has been more controversial. Recent publications have show that PLMS do not cause either subjective or objective sleepiness, but may be a marker for respiratory effort related arousals. In regards to patients with end-stage renal disease, PLMS may mark mortality. In this same group of patients, gabapentin and normalization of hematocrit may be effective therapies for RLS/PLMS. Melatonin may prove to be an alternative therapy for PLMS.

Address: Division of Pulmonary and Critical Care Medicine, University of Kentucky College of Medicine, Lexington, USA. [email protected]

DOI: 10.1097/00063198-200211000-00002

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MeSH Terms: Anemia, Iron-Deficiency, Anticonvulsants, Humans, Melatonin, Nocturnal Myoclonus Syndrome, Renal Insufficiency, Restless Legs Syndrome, Risk Factors