Relationship of Subclinical Hypothyroidism on Epicardial Adipose Tissue: A Systematic Review and Meta-Analysis.

Cecilia Closs, Hernando Vargas-Uricoechea, Diego Schwarzstein, Martin Lobo, Elena Lagranja, Eddison Godinez-Leiva, Juan Patricio Nogueira

Journal: Current problems in cardiology 2023;48(7):101674

PMID: 36841317

Full Text on Elsevier Science View on PubMed

Abstract

Accumulation of epicardial adipose tissue (EAT) and Subclinical hypothyroidism (SH) are associated with increased cardio-metabolic risk. The objective of this study was to quantitatively compare EAT thickening between patients with SH and healthy controls. Therefore, after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases; we analyzed a group of observational studies who compare the EAT changes between SH vs control groups. A total of 9 studies were included in the final analysis, for a total of 424 patients with SH and 330 controls. Random or fixed effects models were used. Pooled analysis revealed that HS increased EAT (MD: 1.0 mm [0.40; 1.50]; P < 0.01). This meta-analysis suggests that the amount of EAT is significantly increased in SH patients. EAT might be a marker of cardiovascular risk in patients with SH.

Address: Melian Medical Center, Formosa, Argentina; Endocrinology Service, Central Hospital of Formosa, Formosa, Argentina.; Director of Metabolic Diseases Study Group, Department of Internal Medicine, Universidad del Cauca, Popayán, Cauca, Colombia.; Endocrinology Service of Integrated Clinics of Rosario, Rosario, Argentina.; Council of Epidemiology and Prevention, Argentine Society of Cardiology, Buenos Aires, Argentina.; Center for Research in Endocrinology, Nutrition and Metabolism, Faculty of Health Sciences, National University of Formosa, Formosa, Argentina.; Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL.; Center for Research in Endocrinology, Nutrition and Metabolism, Faculty of Health Sciences, National University of Formosa, Formosa, Argentina. Electronic address: [email protected].

DOI: 10.1016/j.cpcardiol.2023.101674

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MeSH Terms: Humans, Hypothyroidism, Obesity, Pericardium, Adipose Tissue, Heart Disease Risk Factors, Risk Factors