Age-Associated Abnormalities of Water Homeostasis.

Laura E Cowen, Steven P Hodak, Joseph G Verbalis

Journal: Endocrinology and metabolism clinics of North America 2023;52(2):277-293

PMID: 36948780

Full Text on Elsevier Science View on PubMed

Abstract

Deficits in renal function, thirst, and responses to osmotic and volume stimulation have been repeatedly demonstrated in older populations. The lessons learned over the past six decades serve to emphasize the fragile nature of water balance characteristic of aging. Older individuals are at increased risk for disturbances of water homeostasis due to both intrinsic disease and iatrogenic causes. These disturbances have real-life clinical implications in terms of neurocognitive effects, falls, hospital readmission and need for long-term care, incidence of bone fracture, osteoporosis, and mortality.

Address: Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA.; Division of Endocrinology and Metabolism, New York University, New York, NY 10016, USA.; Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA. Electronic address: [email protected].

DOI: 10.1016/j.ecl.2022.11.002

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MeSH Terms: Humans, Aged, Water-Electrolyte Balance, Homeostasis, Thirst, Aging, Water, Hyponatremia