The impact of Emblica Officinalis (Amla) on lipid profile, glucose, and C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.

Leila Setayesh, Neda Haghighat, Niloufar Rasaei, Mahbobe Rezaei, Krista Casazza, Maryam Nadery, Ileyar Yamrali, Mohammad Zamani, Omid Asbaghi

Journal: Diabetes & metabolic syndrome 2023;17(3):102729

PMID: 36934568

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND AND AIMS

Emblica Officinalis (Amla) is a plant often utilized in traditional medicine due to its purported anti-inflammatory, antioxidant, hypoglycemic, and hypolipidemic properties. However, current evidence regarding its potential for preventing and treating metabolic abnormalities associated with chronic diseases remains unclear.

METHODS

This systematic review and meta-analysis aimed to examine the effects of Amla supplementation on lipid profile, glucose, and C-reactive protein (CRP) concentrations in adults. We completed a systematic search (current as of December 2022) of all available randomized controlled trials (RCTs) in the database including ISI Web of Science, PubMed, Scopus, and Embase. Any effect's mean difference (MD) was calculated using a random-effects model. Weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated also calculated using a random-effects model.

RESULTS

Five RTCs were included in the meta-analysis. Following Amla supplementation, pooled results showed a significant reduction in CRP (p = 0.002), fasting blood glucose (FBG) (p < 0.001), low-density lipoprotein cholesterol (LDL-c) (p < 0.001), total cholesterol (TC) (p < 0.001), and serum triglyceride (TG) (p < 0.001) concentrations as well as an increase in high-density lipoprotein cholesterol (HDL-c) (p < 0.001). The baseline concentration of biochemical indicators was used for subgroup analysis.

CONCLUSION

Amla supplementation shows promise for improving metabolic parameters in adults. In general, the populations included in the analysis were generally 40-58 years with an average BMI of 25.5 and a length of intervention ranging from 3 to 12 weeks. Thus additional investigations are warranted to confirm and expand the findings presented herein.

Address: Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address: [email protected].; Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: [email protected].; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; The Water School, Florida Gulf Coast University, Florida, United States. Electronic address: [email protected].; Ph.D. Student at the Department of Dietetics and Nutrition Robert Stempel College of Public Health & Social Work Florida International University, United States. Electronic address: [email protected].; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.dsx.2023.102729

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MeSH Terms: Humans, Adult, Glucose, C-Reactive Protein, Phyllanthus emblica, Randomized Controlled Trials as Topic, Cholesterol, HDL, Dietary Supplements