Polysaccharides-based nanocarriers enhance the anti-inflammatory effect of curcumin.

Wei Luo, Liangyu Bai, Jing Zhang, Zhangwang Li, Yinuo Liu, Xiaoyi Tang, Panpan Xia, Minxuan Xu, Ao Shi, Xiao Liu, Deju Zhang, Peng Yu

Journal: Carbohydrate polymers 2023;311():120718

PMID: 37028867

Full Text on Elsevier Science View on PubMed

Abstract

Curcumin (CUR) has been discovered to have many biological activities, including anti-inflammatory, anti-cancer, anti-oxygenation, anti-human immunodeficiency virus, anti-microbial and exhibits a good effect on the prevention and treatment of many diseases. However, the limited properties of CUR, including the poor solubility, bioavailability and instability caused by enzymes, light, metal irons, and oxygen, have compelled researchers to turn their attention to drug carrier application to overcome these drawbacks. Encapsulation may provide potential protective effects to the embedding materials and/or have a synergistic effect with them. Therefore, nanocarriers, especially polysaccharides-based nanocarriers, have been developed in many studies to enhance the anti-inflammatory capacity of CUR. Consequently, it's critical to review current advancements in the encapsulation of CUR using polysaccharides-based nanocarriers, as well as further study the potential mechanisms of action where polysaccharides-based CUR nanoparticles (the complex nanoparticles/Nano CUR-delivery systems) exhibit their anti-inflammatory effects. This work suggests that polysaccharides-based nanocarriers will be a thriving field in the treatment of inflammation and inflammation-related diseases.

Address: Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.; The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Institute for the Study of Endocrinology and Metabolism in Jiangxi Province, Nanchang 330006, China; Branch of Nationlal Clinical Research Center for Metabolic Diseases, Nanchang 330006, China.; School of Medicine, St.George University of London, London, UK.; Cardiology Department, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.; Food and Nutritional Sciences, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong. Electronic address: [email protected].; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Institute for the Study of Endocrinology and Metabolism in Jiangxi Province, Nanchang 330006, China; Branch of Nationlal Clinical Research Center for Metabolic Diseases, Nanchang 330006, China. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2023.120718

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MeSH Terms: Humans, Curcumin, Drug Carriers, Nanoparticles, Polysaccharides, Inflammation