New Isocoumarins from the Marine Fungus sp. WP-26.

Pei Wang, Huifang Wang, Juchun Yang, Li Yang, Caihong Cai, Jingzhe Yuan, Fei Wu, Cuijuan Gai, Wenli Mei, Haofu Dai

Journal: Marine drugs 2023;21(3):150

PMID: 36976199

Abstract

Five new isocoumarins, phaeosphaerins A-E (-), were isolated from the fermentation broth of the marine fungus sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (), and two known pimarane-type diterpenes, diaportheins A () and B (). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds - displayed weak neuroprotective effects against HO-induced damage in SH-SY5Y cells. Moreover, compound showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.

Address: Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.; School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530000, China.

DOI: 10.3390/md21030150

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https://medlineplus.gov/neuroblastoma.html

MeSH Terms: Humans, Isocoumarins, Hydrogen Peroxide, Neuroblastoma, Ascomycota, Magnetic Resonance Spectroscopy, Abietanes, Molecular Structure