Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice.

Kelly Lambert, Robert Gardos, Helen Coolican, Lauren Pickel, Hoon-Ki Sung, Angela Yee-Moon Wang, Albert Cm Ong

Journal: Seminars in nephrology 2023;43(2):151405

PMID: 37542985

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Abstract

Polycystic kidney disease (PKD) is a chronic, progressive hereditary condition characterized by abnormal development and growth of cysts in the kidneys and other organs. There is increasing interest in exploring whether dietary modifications may prevent or slow the disease course in people with PKD. Although vasopressin-receptor agonists have emerged as a novel drug treatment in advancing care for people with PKD, several recent landmark trials and clinical discoveries also have provided new insights into potential dietary-related therapeutic strategies. In this review, we summarize the current evidence pertaining to nutrients, foods, dietary patterns, cyst growth, and progression of PKD. We also describe existing evidence-based dietary care for people with PKD and outline the potential implications for advancing evidence-based dietary interventions. Semin Nephrol 43:x-xx © 2023 Elsevier Inc. All rights reserved.

Address: Nutrition and Dietetics, School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address: [email protected].; PKD Australia, Sydney, New South Wales, Australia.; The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR, China.; Academic Nephrology Unit, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

DOI: 10.1016/j.semnephrol.2023.151405

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MeSH Terms: Humans, Polycystic Kidney Diseases, Kidney, Diet, Nutrients