A review of study designs and data analyses in metabolomics studies in myopia.

Xiao-Wen Hou, Ying Wang, Qian Wu, Chaofu Ke, Chen-Wei Pan

Journal: Analytical biochemistry 2022;655():114850

PMID: 35970413

Full Text on Elsevier Science View on PubMed

Abstract

Metabolomics analyzes the entire range of small molecule metabolites in biological systems to reveal the response signals that are transmitted from "genetics and environment", which could help us understand complex phenotypes of diseases. Metabolomics has been successfully applied to the study of eye diseases including age-related macular degeneration, glaucoma, and diabetic retinopathy. In this review, we summarize the findings of myopic metabolomics and discuss them from a design and analysis perspective. Finally, we provide new ideas for the future development of myopia metabolomics research based on the broader ocular metabolomics study.

Address: School of Public Health, Medical College of Soochow University, Suzhou, China.; School of Public Health, Medical College of Soochow University, Suzhou, China. Electronic address: [email protected].

DOI: 10.1016/j.ab.2022.114850

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MeSH Terms: Data Analysis, Humans, Metabolomics, Myopia