Archaea from the gut microbiota of humans: Could be linked to chronic diseases?

Denise Mafra, Marcia Ribeiro, Larissa Fonseca, Bruna Regis, Ludmila F M F Cardozo, Henrique Fragoso Dos Santos, Hugo Emiliano de Jesus, Junia Schultz, Paul G Shiels, Peter Stenvinkel, Alexandre Rosado

Journal: Anaerobe 2022;77():102629

PMID: 35985606

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Abstract

Archaea comprise a unique domain of organisms with distinct biochemical and genetic differences from bacteria. Methane-forming archaea, methanogens, constitute the predominant group of archaea in the human gut microbiota, with Methanobrevibacter smithii being the most prevalent. However, the effect of methanogenic archaea and their methane production on chronic disease remains controversial. As perturbation of the microbiota is a feature of chronic conditions, such as cardiovascular disease, neurodegenerative diseases and chronic kidney disease, assessing the influence of archaea could provide a new clue to mitigating adverse effects associated with dysbiosis. In this review, we will discuss the putative role of archaea in the gut microbiota in humans and the possible link to chronic diseases.

Address: Graduate Program in Biological Sciences - Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, (RJ), Brazil; Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, Brazil; Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Brazil. Electronic address: [email protected].; Graduate Program in Biological Sciences - Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, (RJ), Brazil.; Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Brazil.; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Brazil.; Department of Marine Biology, Fluminense Federal University (UFF), Niterói, RJ, Brazil.; Microbial Ecogenomics and Biotechnology Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Makkah, 23955, Saudi Arabia.; Wolfson Wohl Translational Research Centre, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH, UK.; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Stockholm, Sweden.

DOI: 10.1016/j.anaerobe.2022.102629

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MeSH Terms: Humans, Archaea, Gastrointestinal Microbiome, Methanobrevibacter, Euryarchaeota, Methane, Chronic Disease